Monolith X
Characterize your most challenging interactions
Knowing the strength of the interactions between key players will give you the insights you need to understand the details behind how biological systems work.
If you’re having difficulty studying challenging interactions that include membrane proteins, PROTACs, intrinsically disordered proteins (IDPs), or RNA-based therapeutics, you’ll need Monolith to characterize them.
Monolith comes with MST and enables you to measure high affinity interactions in the pM range, work label-free, or use GFP-tagged proteins.
Monolith X is equipped with Spectral Shift and MST technologies and provides you high quality data with little to no assay development.
Biomolecular InteractionsMeasure high and low affinities in the same system
Broad application rangeProtein, small molecules, nucleic acids, vesicles, plaetlets and whole cells, virus particles and empty capsids
Retain native conformationImmobilization free, in-solution measurements
StoichiometryCalculate molecular ratios of binding partners
Low sample consumptionMinimal concentration (pM/nM) and small volume (<4 µl)
ThermodynamicsDerive ΔG, ΔH and ΔS from calculated Kds
Fast measurementAccess affinities (Kd) in 10 minutes
Capillary technologiesFree of fluidics, no regular maintenance
