Dianthus
For your challenging affinity screening
Dianthus is a plate-based, microfluidics-free screening platform that requires no surface immobilization, and measures under controlled equilibrium conditions – perfect for challenging affinity screenings.
Now with Spectral Shift Technologies and TRIC for measuring molecular interactions, the combined biophysical modalities that has the sensitivity to identify more binders and fewer false negatives. You can work on real-life samples with no concern with aggregates, impurities, or precipitates.
Ideal for challenging molecules
Fragment libraries
Dianthus overcomes both issues with mass-independent measurements and an ability to detect a broad range of affinities.
PROTACs and other protein degraders
With Dianthus, measurements are done in solution and are mass-independent — just what your PROTAC screening project needs.
Intrinsically disordered proteins (IDPs)
Dianthus uses low target concentrations, aggregation of the IDPs won’t get in the way of screening for binders.
Fast hit screening384-well barcoded plate for TRIC measurement
Minimal sample requiredPerform high-throughput particle classification
Capillary technologiesFree of fluidics, no regular maintenance
Board concentration rangePicomolar to millimolar binding affinities
Orthogonal validationValidate hits and leads identified by other biophysical methods.
Analyze under native conditionsImmobilization free, in-solution measurement
